Polyether_Polyether Polyol Knowledge verapamil hydrochloride

verapamil hydrochloride

Verapamil hydrochloride structural formula

Structural formula

Business number 03YU
Molecular formula C27H39N2O4Cl
Molecular weight 491.06
label

verapamil hydrochloride,

alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-alpha-isopropyl-3,4-dimethoxyphenylacetonitrile hydrochloride,

5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride

Numbering system

CAS number:152-11-4

MDL number:MFCD00055208

EINECS number:205-800-5

RTECS number:YV8320000

BRN number:3647093

PubChem number:24277881

Physical property data

1. Physical property data:


1. Melting point (ºC): 142ºC

Toxicological data

2. Toxicological data:


1, acute toxicity: rat oral LD50: 108 mg/kg;


Rat abdominal cavity LD50: 60 mg/kg;


Rat subcutaneous LD50: 107 mg/kg;


Rat intravenous LD50: 16 ug/kg.

Ecological data

3. Ecological data:


Other harmful Effect: This substance may be harmful to the environment, and special attention should be paid to water bodies.

Molecular structure data


5. Molecular property data:


1. Molar refractive index:131.86


2. Molar volume (m3/mol):429.3


3. Isotonic specific volume (90.2K): 1063.9


4. Surface tension (dyne/cm): 37.6


5. Polarizability10-24cm3): 52.27

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 1

3. Number of hydrogen bond acceptors: 6

4. Number of rotatable chemical bonds: 13

5. Number of tautomers: none

6. Topological molecule polar surface area 64

7. Number of heavy atoms: 34

8. Surface charge: 0

9. Complexity: 606

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 1

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 2

Properties and stability

Stable under normal temperature and pressure.

Incompatible materials:Strong oxidizing agent

Storage method

Seal and store in a dry and cool place.

Synthesis method

Made from guaiacol as raw material.

Purpose

Mainly used for paroxysmal supraventricular tachycardia, also used for angina pectoris and hypertension and hypertrophic infarct cardiomyopathy.

S style=”FONT-SIZE: 9pt; FONT-FAMILY: Arial; mso-fareast-font-family: Arial”>4. Surface tension (dyne/cm): 37.6


5. Polarizability10-24cm3): 52.27

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 1

3. Number of hydrogen bond acceptors: 6

4. Number of rotatable chemical bonds: 13

5. Number of tautomers: none

6. Topological molecule polar surface area 64

7. Number of heavy atoms: 34

8. Surface charge: 0

9. Complexity: 606

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 1

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 2

Properties and stability

Stable under normal temperature and pressure.

Incompatible materials:Strong oxidizing agent

Storage method

Seal and store in a dry and cool place.

Synthesis method

Made from guaiacol as raw material.

Purpose

Mainly used for paroxysmal supraventricular tachycardia, also used for angina pectoris and hypertension and hypertrophic infarct cardiomyopathy.

This article is from the Internet, does not represent the position of Toluene diisocyanate reproduced please specify the source.https://www.polyether-factory.com/archives/18402

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