Polyether_Polyether Polyol Knowledge Salicylamide o-Hydroxybenzamide

Salicylamide o-Hydroxybenzamide

Salicylamide Structural Formula

Structural formula

Business number 01DT
Molecular formula C7H7NO2
Molecular weight 137.14
label

2-Hydroxybenzamide,

Salicylamide,

2-Hydroxybenzamide,

2-(HO)C6H4CONH2

Numbering system

CAS number:65-45-2

MDL number:MFCD00007978

EINECS number:200-609-3

RTECS number:VN6475000

BRN number:742439

PubChem ID:None

Physical property data

1. Character:White or slightly pink crystalline powder. Slightly bitter


2. Density (g/mL,25/4):1.175


3. Relative vapor density (g/mL,AIR=1): Unsure


4. Melting point (ºC):140-144 (lit.)


5. Boiling point (ºC,Normal pressure):270


6. Boiling point (ºC, 5.2kPa): Unsure


7. Refractive index:Not sure


8. Flash Point (ºC,14mmHg):181


9. Specific optical rotation (º): Unsure


10. Autoignition point or ignition temperature (ºC): Unsure


11. Vapor pressure (kPa,25ºC): Unsure


2. Molar volume (m3/mol):106.5


3. isotonic specific volume (90.2K):296.7


4. Surface Tension (dyne/cm):60.1


5. Polarizability10-24cm3):14.69

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 2

3. Number of hydrogen bond acceptors: 2

4. Number of rotatable chemical bonds: 1

5. Number of tautomers: 7

6. Topological molecule polar surface area 63.3

7. Number of heavy atoms: 10

8. Surface charge: 0

9. Complexity: 136

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

None yet

Storage method

This product should be sealed, dry and protected from light.

Synthesis method

Combine methyl salicylate and 25% ammonia in 20 Stir closedly 3h, and then in30-40Stir5h. Cool and acidify the reaction solution to pH3-4, and salicylic acid crystals will precipitate. In industrial production, sodium metabisulfite can also be added to the aqueous solution of salicylic acid, and then passed through the ammonia reaction. The yield is 90% and above.

Purpose

for organic synthesis. Medical research. Anticorrosive.
This product is an antipyretic and analgesic drug, and is also used to prepare o-ethoxybenzamide (i.e., analgesic) and other drugs. Orally administered LD50 to mice is 1.4g/kg.

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Synthesis method

Combine methyl salicylate and 25% ammonia in 20 Stir closedly 3h, and then in30-40Stir5h. Cool and acidify the reaction solution to pH3-4, and salicylic acid crystals will precipitate. In industrial production, sodium metabisulfite can also be added to the aqueous solution of salicylic acid, and then passed through the ammonia reaction. The yield is 90% and above.

Purpose

for organic synthesis. Medical research. Anticorrosive.
This product is an antipyretic and analgesic drug, and is also used to prepare o-ethoxybenzamide (i.e., analgesic) and other drugs. Orally administered LD50 to mice is 1.4g/kg.

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