Azaserine Azaserine

diazoserine structural formula

Structural formula

Business number 037H
Molecular formula C5H7N3O4
Molecular weight 173.13
label

azoserine,

o-Diazoacetyl-l-serine,

aliphatic compounds

Numbering system

CAS number:115-02-6

MDL number:MFCD00036802

EINECS number:204-061-6

RTECS number:None

BRN number:1726602

PubChem ID:None

Physical property data

1. Characteristics: light yellow to green Rhomboidal crystal. Maximum absorption wavelength 250.5nm (pH7, E1%/1cm 1140)252nm(0.1mol/L NaOH,E1%/1cm 1230).


2. Density (g/mL,25/4): Undetermined


3. Relative vapor density (g/mL,Air=1): Undetermined


4. Melting point (ºC): 146-162( Decomposed)


5. Boiling point (ºC,normal pressure): Undetermined


6. Boiling point (ºC,5.2kPa): Not determined


7. Refractive index: Undetermined


8. Flashpoint (ºC): Undetermined


9. Specific optical rotation (º): [a]27.5/D-0.5° (c=8.46, in water, pH5.18).


10. Autoignition point or ignition temperature (ºC): Undetermined


11. Vapor pressure (kPa,25ºC): Undetermined


12. Saturated vapor pressure (kPa,60ºC): Undetermined


13. Heat of combustion (KJ/mol): Undetermined


14. Critical temperature (ºC): Undetermined


15. Critical pressure (KPa): Undetermined


16. Oil and water (octanol/Log value of the partition coefficient for water: undetermined


10. Autoignition point or ignition temperature (ºC): Undetermined


11. Vapor pressure (kPa,25ºC): Undetermined


12. Saturated vapor pressure (kPa,60ºC): Undetermined


13. Heat of combustion (KJ/mol): Undetermined


14. Critical temperature (ºC): Undetermined


15. Critical pressure (KPa): Undetermined


16. Oil and water (octanol/Log value of the partition coefficient for water: undetermined


17. Explosion limit (%,V/V): Undetermined


18. Lower explosion limit (%,V/V): Undetermined


19. Solubility: Very soluble Soluble in water, soluble in aqueous ethanol, slightly soluble in methanol, absolute ethanol and acetone. Aqueous solutions are most stable at pH8, and pH is higher or lower than 8 When , the stability decreases rapidly, and the neutral liquid can “℃”>100℃Heat 5 minutes. Incompatible with acids.

Toxicological data

None yet

Ecological data

None yet

Molecular structure data

None yet

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): -2

2. Number of hydrogen bond donors: 2

3. Number of hydrogen bond acceptors: 6

p>

4. Number of rotatable chemical bonds: 4

5. Number of tautomers: none

6. Topological molecule polar surface area 124

7. Number of heavy atoms: 12

8. Surface charge: 0

9. Complexity: 240

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 1

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 1

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

None yet

Storage method


Stored in a cool, ventilated warehouse. Keep away from fire and heat sources. They should be stored separately from oxidants, etc. and avoid mixed storage. Equipped with corresponding varieties and quantities of fire-fighting equipment. The storage area should be equipped with leakage emergency treatment equipment
Prepare and appropriate containment materials.


Synthesis method

Available by Diazoserine is extracted from the fermentation broth of actinomycetes and can also be synthesized by chemical methods.

Purpose

For transplantation of bacteria, molds, and animals and plants It has inhibitory effect on tumors. It is mainly used to treat acute leukemia and certain tumors and can be taken orally.

��; mso-bidi-font-family: 宋体; mso-font-kerning: 0pt”>17. Explosion Upper limit (%,V/V): Undetermined


18. Lower explosion limit (%,V/V): Undetermined


19. Solubility: Very soluble Soluble in water, soluble in aqueous ethanol, slightly soluble in methanol, absolute ethanol and acetone. Aqueous solutions are most stable at pH8, and pH is higher or lower than 8 When , the stability decreases rapidly, and the neutral liquid can “℃”>100℃Heat 5 minutes. Incompatible with acids.

Toxicological data

None yet

Ecological data

None yet

Molecular structure data

None yet

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): -2

2. Number of hydrogen bond donors: 2

3. Number of hydrogen bond acceptors: 6

p>

4. Number of rotatable chemical bonds: 4

5. Number of tautomers: none

6. Topological molecule polar surface area 124

7. Number of heavy atoms: 12

8. Surface charge: 0

9. Complexity: 240

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 1

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 1

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

None yet

Storage method


Stored in a cool, ventilated warehouse. Keep away from fire and heat sources. They should be stored separately from oxidants, etc. and avoid mixed storage. Equipped with corresponding varieties and quantities of fire-fighting equipment. The storage area should be equipped with leakage emergency treatment equipment
Prepare and appropriate containment materials.


Synthesis method

Available by Diazoserine is extracted from the fermentation broth of actinomycetes and can also be synthesized by chemical methods.

Purpose

For transplantation of bacteria, molds, and animals and plants It has inhibitory effect on tumors. It is mainly used to treat acute leukemia and certain tumors and can be taken orally.

This article is from the Internet, does not represent the position of Toluene diisocyanate reproduced please specify the source.https://www.polyether-factory.com/archives/17393

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