1-Naphthylthiourea

Structural formula

• Numbering system
• Physical property data
• Toxicological data
• Ecological data
• Molecular structure data
• Computing chemical data
• More
  • Properties and Stability
  • Storage method
  • Synthesis method
  • Purpose

Numbering system

CAS number:86-88-4

MDL number:MFCD00041824

EINECS number:201-706-3

RTECS number:YT9275000

BRN number:778118

PubChem number:24868783

Physical property data

1. Properties: White prismatic crystals are obtained from alcohol. Odorless, bitter, and highly toxic.

2. Density (g/mL, 25/4℃): Undetermined

3. Relative vapor density (g/mL, air=1): Undetermined

4. Melting point (ºC): 198℃

5. Boiling point (ºC, normal pressure): Undetermined

6. Boiling point (ºC, 5.2kPa): Undetermined Determined

7. Refractive index: Undetermined

8. Flash point (ºC): Undetermined

9. Specific rotation (º): Undetermined

10. Autoignition point or ignition temperature (ºC): Undetermined

11. Vapor pressure (kPa, 25ºC): Undetermined

12. Saturation Vapor pressure (kPa, 60ºC): Undetermined

13. Heat of combustion (KJ/mol): Undetermined

14. Critical temperature (ºC): Undetermined

15. Critical pressure (KPa): Undetermined

16. Log value of oil-water (octanol/water) partition coefficient: Undetermined

17. Explosion upper limit (% , V/V): Undetermined

18. Lower explosion limit (%, V/V): Undetermined 19. Solubility: Solubility in water at 25°C is 0.06g/100ml, solubility in propanol It is 2.43g/100ml and is easily soluble in hot ethanol.

Toxicological data

Norwegian rat acute oral LD₅₀ is 6-8mg/kg > dog oral LD₅₀ is 380mg/ kg, the oral LD₅₀ for monkeys is 4250 mg/kg, the minimum lethal dose for humans is 588 mg/kg, and the LD₅₀ for cats is 100 mg/kg.

Ecological data

None yet

Molecular structure data

1. �Er refractive index: 64.52

2, Molar volume (cm³/mol): 151.6

3, Isotonic specific volume (90.2K): 445.5

4. Surface tension (dyne/cm): 74.4

5. Polarizability (10^-24cm³) ：25.58

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 2

3. Number of hydrogen bond acceptors: 1

4. Number of rotatable chemical bonds: 1

5. Number of tautomers: 3

6. Topological molecule polar surface area 70.1

7. Number of heavy atoms: 14

8. Surface charge: 0

9. Complexity: 217

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

None yet

Storage method

This product should be kept sealed, dry and protected from light.

Synthesis method

1.Antuo is produced by the reaction of α-naphthylamine and ammonium thiocyanate.
2.Preparation method two

3.Preparation method three

Purpose

Thiocarbamide acute rodenticide. It has strong selectivity and is mainly used to control Rattus norvegicus and Yellow-haired Rat. It has low toxicity to other rat species. This agent has a strong stomach poisoning effect and can also damage the respiratory system of rats. Generally, death occurs within 6 to 72 hours after eating. Antuo has good palatability and is ideal for initial use. However, after ingestion of sub-lethal doses, it will develop strong drug resistance. The drug resistance can be increased by 7 to 50 times, and it will develop cross-resistance to other thiourea derivatives. It is advisable to prepare poisonous baits to control rodents. The active ingredients of poisonous baits are 0.5% to 2%. The preparation method is the same as zinc phosphide rodenticide. Example 1: 0.5% Antuo carrot poison bait (or use fruits or vegetables instead), place 2 to 3 piles in each room, each pile contains 10 to 20g of poison bait, and recover the remaining poison bait after 3 days. Example 2: 1 part Antuo raw powder, 1 part fish bone meal, 1 part edible oil, 97 parts cornmeal, mix evenly, then add appropriate amount of water to form a dough, and make poison bait pills the size of soybeans, put 2 to 3 piles in each room. 10-20g per pile is very effective in controlling Rattus norvegicus. It can also be made into 2% safe wheat poison bait for use.