chlorpropamide

Chlorpropamide structural formula

Structural formula

Business number 027D
Molecular formula C10H13ClN2O3S
Molecular weight 276.74
label

1-(4-chlorophenylsulfonyl)-3-propylurea,

p-chlorophenylsulfonamide,

1-(p-Chlorobenzenesulfonyl)-3-propylurea

Numbering system

CAS number:94-20-2

MDL number:MFCD00079004

EINECS number:202-314-5

RTECS number:YS6650000

BRN number:None

PubChem number:24277701

Physical property data

1. Properties: white crystalline powder, odorless and tasteless.

2. Density (g/mL, 25/4℃): Undetermined

3. Relative vapor density (g/mL, air=1): Undetermined

4. Melting point (ºC): 127-129

5. Boiling point (ºC, normal pressure): Undetermined

6. Boiling point (ºC, 5.2kPa): Undetermined

7. Refractive index: Undetermined

8. Flash point (ºC): Undetermined

9. Specific rotation (º): Undetermined Determined

10. Autoignition point or ignition temperature (ºC): Not determined

11. Vapor pressure (kPa, 25ºC): Not determined

12. Saturated vapor pressure (kPa, 60ºC): Undetermined

13. Heat of combustion (KJ/mol): Undetermined

14. Critical temperature (ºC): Undetermined

15. Critical pressure (KPa): Undetermined

16. Log value of oil-water (octanol/water) partition coefficient: Undetermined

17. Explosion upper limit ( %, V/V): Undetermined

18. Lower explosion limit (%, V/V): Undetermined

19. Solubility: Easily soluble in chloroform and acetone, slightly Soluble in ether and benzene, the solubility in water with pH 6 is 2.2mg/ml, and insoluble in water with pH 7.3.

Toxicological data

None yet

Ecological data

None yet

Molecular structure data

1. Molar refractive index: 66.33

2. Molar volume (cm3/mol): 207.4

3. Isotonic specific volume (90.2K ): 542.3

4. Surface tension (dyne/cm): 46.7

5. Polarizability (10-24cm3): 26.29

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 2

3. Number of hydrogen bond acceptors: 3

4. Number of rotatable chemical bonds: 4

5. Number of tautomers: 3

6. Topological molecule polar surface area 83.6

7. Number of heavy atoms: 17

8. Surface charge: 0

9. Complexity: 345

10. Number of isotope atoms: 0

11. Determining the atomic configurationNumber of stereocenters: 0

12. Uncertain number of stereocenters of atoms: 0

13. Determined number of stereocenters of chemical bonds: 0

14. Uncertain Number of stereocenters of chemical bonds: 0

15. Number of covalent bond units: 1

Properties and stability

None yet

Storage method

This product should be kept sealed.

Synthesis method

P-chlorobenzenesulfonylpropionamide sodium salt is obtained by reacting p-chlorobenzenesulfonamide and butanamide. Then acidify and refine with hydrochloric acid to obtain the finished product. Another method is to use p-chlorobenzenesulfonamide, propyl isocyanate, and triethylamine as raw materials.

Purpose

UV absorber. Mainly used in sunscreen and tanning cosmetics, it is chemically stable to light and air, safe for the skin, and has the ability to form a film on the skin. Can effectively absorb U. V. B area 280-320μm medium wave light area) ultraviolet light. The added amount is usually about 4%.

Sulfonylureas are oral hypoglycemic drugs. It has a strong and long-lasting effect, mainly selectively acting on pancreatic islet-β-cells, promoting the secretion of pancreatic islets and lowering blood sugar. Used for diabetes. Chlorpropamide has relatively serious side effects, so the use of this drug has been decreasing year by year.

This article is from the Internet, does not represent the position of Toluene diisocyanate reproduced please specify the source.https://www.polyether-factory.com/archives/18773

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