Polyether_Polyether Polyol Knowledge 2-Chlorophenothiazine

2-Chlorophenothiazine

2-chlorophenothiazine structural formula

Structural formula

Business number 024L
Molecular formula C12H8ClNS
Molecular weight 233.72
label

2-Chloro-10H-phenothiazine,

2-Chlorothiodiphenylamine

Numbering system

CAS number:92-39-7

MDL number:MFCD00005016

EINECS number:202-152-5

RTECS number:SN7580000

BRN number:176587

PubChem number:24892856

Physical property data

1. Character:Yellow crystal


2. Density (g/mL,25/4℃): Undetermined


3. Relative vapor density (g/mL,AIR=1): Undetermined


4. Melting point (ºC):196-199(decomposed)


5. Boiling point (ºC,Normal pressure): Undetermined


6. Boiling point (ºC,5.2kPa): Undetermined


7. Refractive Index: Undetermined


8. Flash Point (ºC): Undetermined


9. Specific optical rotation (º): Undetermined


10. Autoignition point or ignition temperature (ºC): Undetermined


11. Vapor pressure (kPa,25ºC): Undetermined


3. Isotonic specific volume (90.2K): 470.9


4. Surface Tension (dyne/cm):54.2


5. Polarizability10-24cm3):26.00

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 1

3. Number of hydrogen bond acceptors: 2

4. Number of rotatable chemical bonds: 0

5. Number of tautomers: none

6. Topological molecule polar surface area 37.3

7. Number of heavy atoms: 15

8. Surface charge: 0

9. Complexity: 236

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

None yet

Storage method

Should be stored away from light.

Synthesis method

Obtained from the cyclization of m-chlorodiphenylamine. Add m-chlorodiphenylamine and sulfur into the reaction pot and raise the temperature to 70, add iodine. Raise to 120 , reduce pressure and discharge hydrogen sulfide, Then heat to168-172 , insulation0.5h. Cool, add chlorobenzene and activated carbon, and heat to reflux 1h. Filter while hot, and cool the filtrate until15</SPANCrystal. Filter, and wash each filter cake with chlorobenzene and ethanol1 Times, get2-Chlorophenothiazine.

Purpose

Pharmaceutical intermediate, used for the preparation of chlorpromazine and perphenazine.

CING: 0.4pt; mso-ascii-font-family: ‘Times New Roman'”>, reduce the pressure to discharge the hydrogen sulfide, and then raise the temperature to 168-172, insulation0.5h. Cool, add chlorobenzene and activated carbon, heat to reflux1h. Filter while hot and cool the filtrate to15Crystal. Filter, and wash each filter cake with chlorobenzene and ethanol1 Times, get2-Chlorophenothiazine.

Purpose

Pharmaceutical intermediate, used for the preparation of chlorpromazine and perphenazine.

This article is from the Internet, does not represent the position of Toluene diisocyanate reproduced please specify the source.https://www.polyether-factory.com/archives/19416

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